top of page
一疊雜誌

International Publications

Sleep Medicine

In 2021, an important paper on iNAP was published in Sleep Medicine, a leading international journal in sleep medicine. The study evaluated the efficacy and safety of the iNAP negative pressure therapy system in Taiwanese patients with obstructive sleep apnea (OSA).

​

The iNAP system offers an alternative treatment option for patients with sleep apnea. The study demonstrated that iNAP can effectively treat OSA, with up to three-quarters of participants showing significant improvement after treatment. The findings indicate that iNAP provides an effective and safe therapeutic solution.

​

This paper was co-authored by Professor Christian Guilleminault of Stanford University, a globally recognized authority in sleep medicine.

Publication List

Journal Paper:

  • Lin HY, Nien CT, Chen CC, Hong II, Lin C, Lin CM. Optimizing treatment of the novel intra-oral negative pressure for obstructive sleep apnea (Intra-oral negative pressure therapy (iNAP) for obstructive sleep apnea: outcome after pressure titration). Sleep Breath. 2025;29:115. doi:10.1007/s11325-025-03263-w.

  • Puvatanond C, Kasemsuk N, Banhiran W. The efficacy and safety of an intraoral negative air pressure device in patients with obstructive sleep apnea: a systematic review and meta-analysis. J Clin Sleep Med. 2025;21(11):1969-1977. doi:10.5664/jcsm.11812.

  • Nag DS, Chatterjee A, Patel R, Sen B, Pal BD, Wadhwa G. Recent advances in managing obstructive sleep apnea. World J Clin Cases. 2024;12(24):5456-5461. doi:10.12998/wjcc.v12.i24.5456.

  • Nilius G, Farid-Moayer M, Lin CM, et al. Multi-center safety and efficacy study of a negative-pressure intraoral device in obstructive sleep apnea. Sleep Med. 2024;119:139-146. doi:10.1016/j.sleep.2024.04.015.

  • Shih HW, Chen YL, Lin HC, Kuo TBJ, Yang CCH, Chiu FH, et al. Potential treatments for epiglottic collapse in obstructive sleep apnea: how modified drug-induced sleep endoscopy help? Otolaryngol Head Neck Surg. 2024;170(3):952-961. doi:10.1002/ohn.572.

  • Verbraecken J. Treatment of obstructive sleep apnea: To apply positive pressure, or negative pressure, that's the question. Sleep Med. 2024;121:15-17. doi:10.1016/j.sleep.2024.06.010.

  • Aboussouan LS. Treatments for obstructive sleep apnea: CPAP and beyond. Cleve Clin J Med. 2023;90(12):755-?. doi:10.3949/ccjm.90a.23032.

  • Cheng CY, Chen CC, Lo MT, et al. Evaluation of efficacy and safety of intraoral negative air pressure device in adults with obstructive sleep apnea in Taiwan. Sleep Med. 2021;81:163-168. doi:10.1016/j.sleep.2021.02.013.

  • Kuo YH, Liu TJ, Chiu FH, Chang Y, Lin CM, Jacobowitz O, Hsu YS. Novel intraoral negative airway pressure in drug-induced sleep endoscopy with target-controlled infusion for obstructive sleep apnea: Anatomical and polysomnographic indices. Nat Sci Sleep. 2021;13:2087-2099. doi:10.2147/NSS.S327770.

  • Tseng YT, Kuo CJ, Lai CY. Evaluating the mechanisms of the innovative negative pressure therapy for obstructive sleep apnea treatment by upper airway dynamic imaging. Fu-Jen J Med. 2021;19:30-38.

  • Hung TC, Liu TJ, Lu TM, et al. Building a model to precisely target the responders of a novel intermittent negative air pressure device-with mechanism definition. Sleep Med. 2020;72:20-27. doi:10.1016/j.sleep.2020.03.014.

  • Yamaguchi Y. The Effect of Intermittent Negative Air Pressure, iNAP® on Subjective Daytime Sleepiness in Middle-aged Patients with Moderate Obstructive Sleep Apnea. J Sleep Disord Ther. 2020;9(5):318.

  • Hung TC, Liu TJ, Hsieh WY, Chen BN, Su WK, Sun KH, et al. A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults. Sleep Breath. 2019;23(3):849-856. doi:10.1007/s11325-018-01778-z.

  • Kuo TBJ, Hong CH, Hsieh IT, Lee GS, Yang CCH. Pilot study of oral negative pressure therapy for obstructive sleep apnea-hypopnea syndrome. Sleep Med Res. 2017;8:27-32.

  • Lorenzi-Filho G, Almeida FR, Strollo PJ. Treating OSA: current and emerging therapies beyond CPAP. Respirology. 2017;22(8):1500-1507. doi:10.1111/resp.13144.

  • Pavwoski P, Shelgikar AV. Treatment options for obstructive sleep apnea. Neurol Clin Pract. 2017;7(1):77-85. doi:10.1212/CPJ.0000000000000320.

  • Camacho M, Song SA, Tolisano AM. Oral pressure therapy (winx) for obstructive sleep apnea: a meta-analysis updating the systematic review. Sleep Breath. 2016;20:1011-1012. doi:10.1007/s11325-016-1350-z.

  • Nigam G, Pathak C, Riaz M. Effectiveness of oral pressure therapy in obstructive sleep apnea: a systematic analysis. Sleep Breath. 2016;20(2):663-671. doi:10.1007/s11325-015-1270-3.

  • Donovan LM, Boeder S, Malhotra A, Patel SR. New developments in the use of positive airway pressure for obstructive sleep apnea. J Thorac Dis. 2015;7(8):1323-1342. doi:10.3978/j.issn.2072-1439.2015.07.30.

  • Girdhar A, Berry RB. A young man running out of treatment options. J Clin Sleep Med. 2015;11(10):1239-1242. doi:10.5664/jcsm.5104.

  • Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Ther Adv Chronic Dis. 2015;6(5):273-285. doi:10.1177/2040622315590318.

  • Freedman N. Improvements in current treatments and emerging therapies for adult obstructive sleep apnea. F1000Prime Rep. 2014;6:36. doi:10.12703/P6-36.

  • Schwab RJ, Kim C, Siegel LC, et al. Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea. Sleep. 2014;37(7):1237-1247. doi:10.5665/sleep.3846.

  • Weaver TE, Calik MW, Farabi SS. Innovative treatments for adults with obstructive sleep apnea. Nat Sci Sleep. 2014;6:137-147. doi:10.2147/NSS.S46818.

  • Barone DA. Alternative devices for obstructive sleep apnea. Neurol Clin Pract. 2013;3(1):67-70. doi:10.1212/CPJ.0b013e318278be88.

  • Colrain IM, Black J, Siegel LC, et al. A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea. Sleep Med. 2013;14(9):830-837. doi:10.1016/j.sleep.2013.05.009.

  • Farid-Moayer M, Siegel LC, Black J. A feasibility evaluation of oral pressure therapy for the treatment of obstructive sleep apnea. Ther Adv Respir Dis. 2013;7(1):3-12. doi:10.1177/1753465812468043.

  • Farid-Moayer M, Siegel LC, Black J. Oral pressure therapy for treatment of obstructive sleep apnea: clinical feasibility. Nat Sci Sleep. 2013;5:53-59. doi:10.2147/NSS.S44736.

  • Park JG, Morgenthaler TM, Gay PC. Novel and emerging nonpositive airway pressure therapies for sleep apnea. Chest. 2013;144(6):1946-1952. doi:10.1378/chest.13-0273.

 
Conference Paper:

  • Georg N et al., A Multi-center, Two-stage, Single-arm, Prospective, First-night Order Cross-over, Evaluator-blind Study to Evaluate the Efficacy, Safety and Tolerance of the iNAP® Sleep Therapy System in Adults with Obstructive Sleep Apnea (OSA)–AN INTERIM ANALYSIS. 27th DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), 2019, Germany.

  • Liu CL et al., Intra-oral negative pressure therapy in patients with obstructive sleep apnea: upper airway imaging in responders vs. nonresponders.  Sleep DownUnder, 2019, Australia.

  • Li HY et al., CPAP離脱者への対応 – How do we manage CPAP failure? 日本睡眠学会第44回定期学術集会, 2019, Japan.

  • Lin CM et al., A Single-center Cross-over and Evaluator-blind Pivotal Study to Evaluate the Efficacy and Safety of intraoral Negative Air Pressure Device in Adults with Obstructive Sleep Apnea. 33rd Annual Meeting of the Associated Professional Sleep Society, 2019, United States.

  • Liu TJ et al., Upper Airway Imaging of Patients with Obstructive Sleep Apnea under Treatment of a Novel Intra‐Oral Negative Pressure Device. 10th International Surgical Sleep Society Meeting, 2019, United States.

  • Liu CL et al., The effective rationale of a novel intra-oral negative pressure device for obstructive sleep apnea. Sleep DownUnder, 2018, Australia.

  • Liu TJ et al., Follow-up Reports on Intraoral Negative Air Pressure Device Treated Patients Underwent Obstructive Sleep Apnea Uvulopalatopharyngoplasty. 9th International Surgical Sleep Society Meeting, 2018, Germany.

  • Hang LW et al., Treatment Outcomes and Safety of a Novel Intraoral Negative Air Pressure Device in the First-in-Man Study. 2nd Congress of Asian Society of Sleep Medicine, 2018, South Korea.

  • Liu TJ et al., Imaging and Treatment Outcomes of the iNAP® Sleep Therapy System in the Feasibility Study in Taiwan. 14th Taiwan Japan Conference on Otolaryngology Head and Neck Surgery, 2017, Taiwan.

  • Liu TJ et al., An Oral Negative Pressure Device for Treatment Obstructive Sleep Apnea (OSA). 25th DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), 2017, Germany.

  • Lin CM et al., A Multicenter Pilot Study on the Indications of the Negative Pressure Sleep Therapy System for the Treatment of Obstructive Sleep Apnea. A Joint Congress of World Association of Sleep Medicine and World Sleep Federation, 2017, Czech Republic.

  • Liu TJ et al., Imaging and Treatment Outcomes of the iNAP® Sleep Therapy System in the Feasibility Study in Taiwan. Network of Asia-Pacific Sleep Specialists, 2016, United States.

  • Lin CM et al., Clinical Efficacy and Safety Evaluation of a Novel Negative Pressure Therapy System for Treatment of Obstructive Sleep Apnea Adult Patients. 4th International Pediatric Sleep Association Congress in conjunction with the 14th annual meeting of Taiwan Society of Sleep Medicine, 2016, Taiwan.

  • Liu TJ et al., Safety and Effectiveness of Intraoral Pressure Gradient Device for Obstructive Sleep Apnea Patients. 6th World Congress on Sleep Medicine, 2015, South Korea.

  • Liu TJ et al., Preliminary result of an oral negative pressure device for treatment obstructive sleep apnea (OSA). 13th Asia-Oceania ORL-HNS Congress, 2015, Taiwan.

  • Emsellem HA et al., Safety and effectiveness of oral pressure therapy with a new oral interface. Sleep, 2014, 37(abstr suppl):A146(4017).

  • Colrain IM et al., Safety and effectiveness of oral pressure therapy: 3-month treatment evaluation. Am J Respir Crit Care Med, 2013, 187:A2119.

  • Patel SR et al., Am J Respir Crit Care Med, 2013, 187:A3752

  • Colrain IM et al., Compliance with oral pressure therapy for treatment of obstructive sleep apnea. Sleep, 2013, 36(abstr suppl):A138(0391).

  • Colrain IM et al., Oral pressure therapy for obstructive sleep apnea in subjects without prior treatment experience. Sleep, 2013, 36(abstr suppl):A175(0504).

  • Colrain IM et al., Oral Pressure Therapy: a new treatment for obstructive sleep apnea. Sleep and Biological Rhythms, 2013, 11 (S2):29-30.

  • Malhotra A, et al., Oral pressure therapy improves obstructive sleep apnea. Am J Respir Crit Care Med, 2012, 185:A6810.

  • Schwab RJ et al., Mechanism of action of a novel device using oral pressure therapy (OPT) for the treatment of OSA. Am J Respir Crit Care Med, 2012, 185:A6811.

  • Colrain IM et al., A multicentre evaluation of oral pressure therapy for the treatment of obstructive sleep apnoea: sleep architecture effects. J Sleep Res, 2012, 21(Suppl 1):P696.

  • Colrain IM et al., A Multi-Centre Evaluation of Oral Pressure Therapy for the Treatment of Obstructive Sleep Apnoea. J Sleep Res 2012, 21(Suppl 1):P697.

  • Schwab RJ et al., Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea. J Sleep Res, 2012, 21(Suppl 1):O310.H.

bottom of page