Clinical

Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder that occurs when the tongue and soft tissue in the back of the throat collapses and blocks the upper airway. This reduces the amount of air getting into the lungs, leading to pauses in breathing.

Long-term consequences of untreated sleep apnea:

  • High blood pressure

  • Heart disease

  • Stroke

  • Pre-diabetes and diabetes

  • Depression

  • Cance

Symptoms of OSA:

  • Loud or frequent snoring

  • Silent pauses in breathing

  • Choking or gasping sounds

  • Daytime sleepiness or fatigue

  • Insomnia or unrefreshing sleep

  • Morning headaches

  • Nocturia (waking during the night to go to the bathroom)

  • Memory or learning problems and loss of concentrate

  • Decreased sexual desire

  • Irritability

What is OSA
How it works
Clinical Evidence

Follow-up Reports on Intraoral Negative Air Pressure Device Treated Patients Underwent Obstructive Sleep Apnea Uvulopalatopharyngoplasty

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Sleep and Breathing, September 2018, Volume 22, Issue 3, pp 865–896

Conference: The 9th International Surgical Sleep Society Meeting, April 2018,  Munich, Germany.

Treatment Outcomes and Safety of a Novel Intraoral Negative Air Pressure Device in the First-in-Man Study

Liang-Wen Hang, Shinn-Jye Liang

Conferance: 2nd Congress of Asian Society of Sleep Medicine, March 2018, Seoul, South Korea.

Imaging and Clinical Evaluation of the Intraoral Negative Air Pressure Device in the Feasibility Study in Taiwan

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: 14th Taiwan Japan Conference on Otolaryngology Head and Neck Surgery, December 2017, Kaohsiung, Taiwan.

An Oral Negative Pressure Device for Treatment of Obstructive Sleep Apnea (OSA)

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: The 25th annual meeting of the DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), November 2017, Münster, Germany.

A Multicenter Pilot Study on the Indications of the Negative Pressure Sleep Therapy System for the Treatment of Obstructive Sleep Apnea

Chia-Mo Lin, Liang-Wen Hang, Kun-Ta Chou, Tien-Jen Liu, Christian Guilleminault

Sleep Medicine, December 2017, Volume 40, Supplement 1, Page e198.

Conference: World Sleep 2017 A Joint Congress of World Association of Sleep Medicine and World Sleep Federation, October 2017, Prague, Czech Republic.

Safety and Effectiveness of Intraoral Pressure Gradient Device for Obstructive Sleep Apnea Patients

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Sleep Medicine, December 2017, Volume 40, Supplement 1, Page e198.

Confrence: The 6th World Congress on Sleep Medicine, March 2015, Seoul, South Korea.

Preliminary Result of an Oral Negative Pressure Device for Treatment of Obstructive Sleep Apnea (OSA)

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: 13th Asia-Oceania ORL-HNS Congress, March 2015, Taipei, Taiwan.

The effective rationale of a novel intra-oral negative pressure device for obstructive sleep apnea

Ching-Lung Liu, Tien-Jen Liu, Ying-Piao Wang, Yi-Shing Leu

Conference: Sleep DownUnder 30th Annual Scientific Meeting of the Australasian Sleep Association and Australasian Sleep Technologists Association, October 2018, Brisbane, Australia.

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