臨床資訊

[ 來源: MarketsandMarkets, Sleep Apnea Diagnostic & Therapeutic Devices Market, MD 1181 | 2012 ]

睡眠障礙問題於全球盛行,來自睡眠呼吸中止因素則占了不少比例,而阻塞性睡眠呼吸中止症(OSA)為最常見的一種型態。研究顯示,患有OSA的人口全球約有一億人,而有高達八成未經診斷與治療。

阻塞性睡眠呼吸中止症(OSA)是一種與睡眠相關的呼吸障礙疾病。發生於睡眠時,舌頭或喉嚨後方的軟組織鬆弛塌陷,造成上呼吸道狹窄或阻塞,減少空氣進入肺部,進而導致呼吸暫停。當呼吸中止造成缺氧時,腦部藉由喚醒人體,以回復正常呼吸。患者經常因呼吸中止從睡夢中醒來,醒後回復正常呼吸,如此反反覆覆每晚可達數十至數百次不等,嚴重干擾睡眠,造成白天精神不濟、無法專心,或是極度嗜睡。

睡眠呼吸中止症未接受治療可能造成之影響:

  • 高血壓

  • 心血管疾病

  • 中風

  • 糖尿病

  • 憂鬱症

  • 癌症

阻塞性睡眠呼吸中止症(OSA)常見症狀:

  • 鼾聲如雷或打鼾頻繁

  • 旁人觀察到睡眠時呼吸中斷無聲現象

  • 睡眠中突然喘氣或大聲吸氣

  • 白天嗜睡或精神不濟

  • 夜晚失眠或睡眠品質差

  • 夜尿(睡眠中斷起身上洗手間)

  • 記憶力減退、學習能力下降或無法集中精神

  • 性慾下降

  • 暴躁易怒

什麼是阻塞性睡眠呼吸中止症 (OSA)?
臨床研究

Follow-up Reports on Intraoral Negative Air Pressure Device Treated Patients Underwent Obstructive Sleep Apnea Uvulopalatopharyngoplasty

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Sleep and Breathing, September 2018, Volume 22, Issue 3, pp 865–896

Conference: The 9th International Surgical Sleep Society Meeting, April 2018,  Munich, Germany.

The effective rationale of a novel intra-oral negative pressure device for obstructive sleep apnea

Ching-Lung Liu, Tien-Jen Liu, Ying-Piao Wang, Yi-Shing Leu

Conference: Sleep DownUnder 30th Annual Scientific Meeting of the Australasian Sleep Association and Australasian Sleep Technologists Association, October 2018, Brisbane, Australia.

Treatment Outcomes and Safety of a Novel Intraoral Negative Air Pressure Device in the First-in-Man Study

Liang-Wen Hang, Shinn-Jye Liang

Conferance: 2nd Congress of Asian Society of Sleep Medicine, March 2018, Seoul, South Korea.

Imaging and Clinical Evaluation of the Intraoral Negative Air Pressure Device in the Feasibility Study in Taiwan

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: 14th Taiwan Japan Conference on Otolaryngology Head and Neck Surgery, December 2017, Kaohsiung, Taiwan.

An Oral Negative Pressure Device for Treatment of Obstructive Sleep Apnea (OSA)

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: The 25th annual meeting of the DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), November 2017, Münster, Germany.

A Multicenter Pilot Study on the Indications of the Negative Pressure Sleep Therapy System for the Treatment of Obstructive Sleep Apnea

Chia-Mo Lin, Liang-Wen Hang, Kun-Ta Chou, Tien-Jen Liu, Christian Guilleminault

Sleep Medicine, December 2017, Volume 40, Supplement 1, Page e198.

Conference: World Sleep 2017 A Joint Congress of World Association of Sleep Medicine and World Sleep Federation, October 2017, Prague, Czech Republic.

Safety and Effectiveness of Intraoral Pressure Gradient Device for Obstructive Sleep Apnea Patients

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Sleep Medicine, December 2017, Volume 40, Supplement 1, Page e198.

Confrence: The 6th World Congress on Sleep Medicine, March 2015, Seoul, South Korea.

Preliminary Result of an Oral Negative Pressure Device for Treatment of Obstructive Sleep Apnea (OSA)

Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su

Conference: 13th Asia-Oceania ORL-HNS Congress, March 2015, Taipei, Taiwan.

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